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Uutinen | 29.5.2023

Masanobu Komatsu luennoi kasvaimen angiogeneesistä syöpäseminaarissa to 8.6. klo 15

Tervetuloa kevään viimeiseen syöpäseminaariin torstaina 8.6. kello 15–16. Liity mukaan tällä Zoom-linkillä.

Puhuja: prof. Masanobu Komatsu, Johns Hopkins School of Medicine, Johns Hopkins All Children’s Hospital, USA. 

Esityksen otsikko: Role of R-Ras in vascular stability: A good neighbor next door
Esitys käsittelee kasvaimen angiogeneesiä.

Host: prof. Tero Järvinen

Esityksen tiivistelmä:

Communications between adjacent endothelial cells and between endothelial cells and pericytes are important for the homeostasis of blood vessels. A Ras homolog GTPase, R-Ras plays crucial roles in the molecular crosstalk between these cells. For instance, quiescent endothelial cells guide the quiescence of neighboring endothelial cells via R-Ras signaling mediated by Akt3 and Jagged1 that results in the upregulation of Notch-target genes such as UNC5B and RRAS itself in the neighboring cells. On the other hand, pericyte contraction controlled by R-Ras leads to the quiescence of neighboring endothelial cells by mechanical activation of latent TGF beta. R-Ras also promotes endothelial lumen formation via Akt-mediated microtubule stabilization. This seminar will present some of the key findings from recent studies and discuss a potential idea for harnessing these molecular pathways for treating vascular disorders.

Poimintoja julkaisuista:

Komatsu M, Ruoslahti E. R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat. Med. 2005, 11, 1346–1350.

Sawada J, Urakami T, Li F, Urakami A, Zhu W, Fukuda M, Li DY, Ruoslahti E, Komatsu M. Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels. Cancer Cell 2012, 22, 235–249.

Li F, Sawada J, Komatsu M. R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature. Nat. Commun. 2017, 8, 1720.

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